In echocardiography, PISA stands for Proximal Isovelocity Surface Area. It’s a Doppler-based method used to quantify the severity of valvular regurgitation, most commonly mitral regurgitation (MR). The effective regurgitant orifice area (EROA) and the regurgitant volume (RVol) are of particular interest in these cases. Boost your accuracy in evaluating mitral regurgitation with these quick PISA method tips and tricks.